Topics

Main research topics of the units affiliated to ED Bio-Santé.

The scopes of research in the 15 teams affiliated to ED Bio-Santé cover a wide range of topics from microbiology to neuro-sciences and from animal models to clinical research.

There are studies on cell biology, physiology and patho-physiology, dealing with cellular homeostasis, apoptosis, neurodegeneratibve diseases and addiction, proliferative disorders in lymphoid and myeloids lineages, prostatic cancer, glioma, cytokines and inflammation, myocyte development and electrical properties, fibrosis, ischemie-reperfusion injury, glycosylation and its consequences on physiological processes.

Even if these topics appear to cover a wide range of research one should notice that the specificity of ED Bio-santé relies on focusing on human health for most of its activities. This is underlined by the importance of research linked to therapeutic aspects and drug design and testing. Some very original approaches are at the core of the laboraties such as antimicrobial resistance and modeling of therapeutic schemes, pharmacology of anti-cancer and immuno-suppressive medicines, cutting edge research on anti-chronic myeloïd leukemias, organ preservation or anti-cancer – drugs in close relationship with chemists, either at local or international level as well as private companies.

Furthermore the theoretical research carried on by most of the teams affiliated to ED Bio-santé relies on a strong opening towards translational research, mostly via the two Clinical Investigation Centers which allow translation of laboratory findings into human applications. One original partner in this process is an experimental animal platform mostly devoted to surgical experiments on large animals (pigs) and organ transplantation (IBiSA : Experimental surgery and transplantation).

The equipments are of course of the higher standards for cell biology, genomics, transcriptomics including several q-PCR, DNA sequencers, CGH -array, as well as proteomics facilities including a SELDI-TOF and very soon a MALDI-TOF-TOF spectrometer. Furthermore a common service team is devoted to microscopy including florimetry, imaging, several confocal machines among them a fast spinning-disk apparatus. Scanning and direct electron microscopy is at hand as well as ionic microscopy. Last but not least the animal facilities are of high standard, the brand new rodent experimental building is under construction and the IBiSA experimental surgery ward is fully operational. The cooperation of INRA at both sites is an important addition to the possibilities of research.

International cooperation is very much welcome as well as cooperation with private entities. Today several projects are conducted under various cooperation frames : academic co-partnering, proof of concept leading to patenting in partnership with several private pharmaceutical firms, development of new tools (molecules, procedures and also instruments) with international groups….

Recherche

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